detection of Streptococcus agalactiae (Group B streptococcusGBS within the placenta is associated with an increased risk of neonatal unit (NNU) admission, according to a study published online on November 29. natural microbiology.
Francesca Gaccioli, Ph.D., from the University of Cambridge, UK, and colleagues reanalyzed a dataset in which GBS DNA was detected in the placentas of about 5 percent of women before the onset of labor in a case-control NNU study. Admission fee.
Researchers found that among full-term infants, 7 of 30 infants with placental GBS and 34 of 406 infants without placental GBS were admitted to NNU (odds ratio , 3.3). In a validation study using non-overlapping subjects from the same cohort, 239 NNU regular admissions and 686 regular controls were studied: 16 out of 36 with placental GBS and 223 out of 889 without placental GBS. were admitted to NNU (odds ratio, 2.4). Of 36 infants with placental GBS, 10, 2, 6, and 5 were admitted to NNU with probable culture-negative sepsis, proven GBS sepsis, chorioamnionitis, and ligamentitis. (odds ratios, 4.8 and 66.6; 5.3 and 6.7, respectively). Fetal cytokine storm was present in 36 percent of infants with placental GBS DNA and in 4 percent of cases with negative placentas (odds ratio, 14.2).
“When analyzed by cause, we found that this association was likely explained by an increased rate of hospitalization for culture-negative sepsis and culture-proven GBS sepsis,” the authors wrote.
Several authors disclosed relationships with the biopharmaceutical industry.
For more information:
Francesca Gaccioli et al, Placental Streptococcus agalactiae DNA is associated with neonatal ward admissions and fetal proinflammatory cytokines in term infants, natural microbiology (2023). DOI: 10.1038/s41564-023-01528-2
Copyright © 2023 health day. All rights reserved.