Suspected bronchiectasis associated with mortality by conventional spirometry

Among adults with a history of smoking and normal spirometry, suspected bronchiectasis is associated with an increased risk of all-cause mortality, a study published online Oct. 3 shows. Became. Annual report of internal medicine.

Alejandro A. Diaz, M.D., MPH, of Brigham and Women’s Hospital in Boston, et al. We examined the association with mortality in adults with . Conventional spirometry, preserved ratio injury spirometry (PRISm), and obstructive spirometry in a prospective observational cohort.

A total of 7,662 non-Hispanic black or white adults aged 45 to 80 years with a smoking history of 10 pack-years or more were included in the Chronic Obstructive Pulmonary Disease Genetic Epidemiology (COPDGene) cohort and stratified for routine spirometry. (3,277 people). , PRISm (986), and occlusive spirometry (3,399).

Overall, 17.6 percent of participants had suspected bronchiectasis. Researchers found that 2,095 participants (27.3 percent) died during a median follow-up of 11 years. The 10-year mortality rate was found to be higher between those suspected of having bronchiectasis and those without (difference in mortality probability). [95 percent confidence intervals]0.15 [0.09 to 0.21]0.07 [−0.003 to 0.15]0.06 [0.03 to 0.09] for conventional spirometry, PRISm, and obstructive spirometry, respectively).

When only computed tomography was used to identify bronchiectasis, the difference decreased in the normal spirometry group (difference in probability of death) [95 percent confidence interval]0.04 [−0.001 to 0.08]).

“We found that suspected bronchiectasis was associated with increased all-cause mortality,” the authors wrote.